@article {PANAGOPOULOS3747, author = {IOANNIS PANAGOPOULOS and LUDMILA GORUNOVA and MARIUS LUND-IVERSEN and SVERRE HEIM}, title = {Monosomy 13 in Mammary Myofibroblastoma}, volume = {41}, number = {8}, pages = {3747--3751}, year = {2021}, doi = {10.21873/anticanres.15166}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Myofibroblastoma of the breast is a rare benign mesenchymal tumor whose morphology is similar to that of spindle-cell lipoma. The few hitherto genetically investigated mammary myofibroblastomas have been shown to have had loss of material from chromosome 13, changes that are also common in spindle-cell lipoma. Our aim was to add to the existing knowledge of genetic aberrations in mammary myofibroblastoma by investigating another such tumor. Materials and Methods: Cytogenetic and array comparative genome hybridization (aCGH) analyses were performed on a surgically removed mammary myofibroblastoma from a 76-year-old man. Results: Short-term cultured cells from the tumor showed the karyotype 45,XY,-13[3]/44~45,idem,add(19)(q13)[cp2]. aCGH detected loss of one entire chromosome 13 and heterozygous loss from 19q between sub-band 19q13.12 and 19qter. Conclusion: These findings add to the evidence that loss of 13q material is typical of mammary myofibroblastomas.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/41/8/3747}, eprint = {https://ar.iiarjournals.org/content/41/8/3747.full.pdf}, journal = {Anticancer Research} }