TY - JOUR T1 - Combining Preoperative Immunoinflammatory Scores and <sup>18</sup>F-Fluorodeoxyglucose Positron-emission Tomography Predicts Beneficiaries of Salvage Esophagectomy JF - Anticancer Research JO - Anticancer Res SP - 4005 LP - 4011 DO - 10.21873/anticanres.15198 VL - 41 IS - 8 AU - MAKOTO SAKAI AU - MAKOTO SOHDA AU - SHINTARO UCHIDA AU - ARISA YAMAGUCHI AU - TAKAYOSHI WATANABE AU - HIDEYUKI SAITO AU - YASUNARI UBUKATA AU - NOBUHIRO NAKAZAWA AU - KENGO KURIYAMA AU - AKIHIKO SANO AU - HIROOMI OGAWA AU - TAKEHIKO YOKOBORI AU - KEN SHIRABE AU - HIROSHI SAEKI Y1 - 2021/08/01 UR - http://ar.iiarjournals.org/content/41/8/4005.abstract N2 - Background: This study evaluated the prognostic value of preoperative immunoinflammatory scores and 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET) for patients undergoing salvage esophagectomy to identify suitable candidates for surgery. Patients and Methods: Twenty-five patients undergoing salvage esophagectomy were included. The prognostic value of the preoperative C-reactive protein-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and maximum standardized FDG uptake value (SUVmax) were investigated. Results: Multivariate analysis demonstrated high CAR to be an independent prognostic factor for overall survival (p=0.013). CAR had no association with clinicopathological variables, whereas the SUVmax was significantly positively associated with tumor aggressiveness. Multivariate analysis using residual tumor and the combination of CAR and SUVmax revealed both residual tumor (p=0.009) and high CAR/high SUVmax (p=0.016) to be independent prognostic factors for overall survival. Conclusion: Preoperative evaluation of CAR as an immunoinflammatory indicator and SUVmax as a marker of tumor aggressiveness will be useful to identify suitable candidates for this high-risk surgery. ER -