RT Journal Article
SR Electronic
T1 Nodular Lymphocyte Predominant Hodgkin Lymphoma With Aberrant Immunophenotype or Variant Histopathology: Insights From Case Series of Three Patients
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4017
OP 4020
DO 10.21873/anticanres.15200
VO 41
IS 8
A1 CHANDER, GURVIN
A1 DASSANAYAKE, HANSINI
A1 KAPAROU, MARIA
A1 AHMED, MARIA
A1 KISHORE, BHUVAN
A1 NIKOLOUSIS, EMMANOUIL
A1 KANELLOPOULOS, ALEXANDROS
YR 2021
UL http://ar.iiarjournals.org/content/41/8/4017.abstract
AB Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with variant histopathology or aberrant immunophenotype is exceedingly rare and there is paucity of data with regards to its clinical characteristics and course. Case Report: Herein, we present three cases of NLPHL with aberrant immunophenotype or variant histopathological picture, which displayed distinct clinical and imaging findings. These case reports involved a patient with CD30 and CD20 positivity without Reed-Sternberg cells present, a NLPHL patient with aggressive, persistent disease activity with progressive transformation to germinal centres, and a patient with combined morphology of NLPHL and classical Hodgkin’s lymphoma. Conclusion: Aberrant immunophenotype/variant NLPHL might represent a distinct form of NLPHL, sharing characteristics with classical Hodgkin, non-Hodgkin lymphomas or benign, progressive transformation of germinal centre lymphadenopathy.