RT Journal Article
SR Electronic
T1 A Possible Definition of Oligometastasis in Pancreatic Cancer and Associated Survival Outcomes
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3933
OP 3940
DO 10.21873/anticanres.15189
VO 41
IS 8
A1 MASAYA YAMANAKA
A1 MASAMICHI HAYASHI
A1 SUGURU YAMADA
A1 FUMINORI SONOHARA
A1 HIDEKI TAKAMI
A1 YOSHIKUNI INOKAWA
A1 DAI SHIMIZU
A1 NORIFUMI HATTORI
A1 MITSURO KANDA
A1 CHIE TANAKA
A1 GORO NAKAYAMA
A1 MASAHIKO KOIKE
A1 YASUHIRO KODERA
YR 2021
UL http://ar.iiarjournals.org/content/41/8/3933.abstract
AB Background: Oligometastatic cancer (OM) is possibly associated with relatively better survival outcomes. We attempted to identify cases in line with this OM concept. Patients and Methods: A total of 130 cases with unresectable metastatic pancreatic cancer underwent non-curative surgery from April 2001 to December 2019. Sites of metastasis, clinicopathological information, and surgical outcomes were collected to formulate a better definition of OM. Results: OM criteria were defined as having metastasis to a single organ, few countable lesions and low serum cancer antigen 19-9 level. The median overall survival after non-curative surgery of OM cases was 13.0 months and was significantly better than that of non-OM cases (8.4 months, p=0.003). Conclusion: We propose single-organ metastasis of limited tumor volume (H1 or P1/2 by the Japanese Society of Cancer of the Colon and Rectum classification) and low serum cancer antigen 19-9 level (<2,000 U/ml) as new criteria for defining OM pancreatic cancer.