PT  - JOURNAL ARTICLE
AU  - SANG HYUP HAN
AU  - JEONG HEE HAN
AU  - SANG HAK HAN
AU  - HAE SUNG KIM
AU  - JIN WON LEE
TI  - Fixation Using Carnoy’s Solution Enables Detection of More Lymph Nodes After Gastrectomy for Gastric Cancer
AID  - 10.21873/anticanres.15191
DP  - 2021 Aug 01
TA  - Anticancer Research
PG  - 3949--3953
VI  - 41
IP  - 8
4099  - http://ar.iiarjournals.org/content/41/8/3949.short
4100  - http://ar.iiarjournals.org/content/41/8/3949.full
SO  - Anticancer Res2021 Aug 01; 41
AB  - Background: To compare the number of lymph nodes (LNs) detected when using Carnoy’s solution (CS) versus 10% neutral buffered formalin (NBF) to fix specimens after radical gastrectomy for gastric cancer. Patients and Methods: LNs were routinely detected using NBF until 2020, since then, for the fixation procedure, residual fat was fixed in CS for 24 hours and dissected again for the detection of further LNs. Of 143 specimens, 117 were included in the NBF group and 26 in the CS group. Results: The mean numbers of LNs examined were 27.85±14.89 and 36.30±12.41 in the NBF and CS groups, respectively (p=0.008). The mean number of additional LNs detected using CS was 8.07±2.91, of which 0.38±1.02 were metastatic. Additional LNs were found in all patients of the CS group, and all were ≤3 mm. Of the 26 patients in the CS group, metastatic LNs were detected in four, disease in two of whom was up-staged. Conclusion: CS is an appropriate alternative to NBF for the fixation of gastric cancer specimens, and more LNs were detected in the resected specimens fixed when using CS compared with NBF.