RT Journal Article SR Electronic T1 Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3815 OP 3823 DO 10.21873/anticanres.15174 VO 41 IS 8 A1 YUTA MUKAE A1 HIDENORI ITO A1 YASUYOSHI MIYATA A1 KYOHEI ARAKI A1 TSUYOSHI MATSUDA A1 NOZOMI AIBARA A1 YUICHIRO NAKAMURA A1 TOMOHIRO MATSUO A1 HIDEKI SAKAI A1 KANAME OHYAMA YR 2021 UL http://ar.iiarjournals.org/content/41/8/3815.abstract AB Background/Aim: A previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior in bladder cancer (BC). We investigated the pathological significance and prognostic roles of urine and tissue levels of CP protein in BC patients. Materials and Methods: Urine CP levels were measured using an enzyme-linked immunosorbent assay in 97 patients. CP expression in BC tissues was evaluated by immunohistochemical analysis in 176 patient samples. Results: Urine CP levels were positively associated with tumor grade and pT stage in non-muscle invasive BC (NMIBC). CP expression in BC tissues was positively associated with tumor growth and progression. Multivariate analysis demonstrated that high urine CP levels was an independent predictor of recurrence in the urinary tract in NMIBC (hazard ratio=2.87, p=0.016). Conclusion: CP-related markers, especially urine CP levels, are useful biomarkers of malignant potential and prognosis in NMIBC.