TY - JOUR T1 - Phase II Study of Nab-paclitaxel Plus Cyclophosphamide Plus Trastuzumab Neoadjuvant Chemotherapy in Early HER-2-positive Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 3899 LP - 3904 DO - 10.21873/anticanres.15185 VL - 41 IS - 8 AU - MISATO OGINO AU - TAKAAKI FUJII AU - YUKIO KOIBUCHI AU - YUKO NAKAZAWA AU - DAISUKE TAKATA AU - KEN SHIRABE Y1 - 2021/08/01 UR - http://ar.iiarjournals.org/content/41/8/3899.abstract N2 - Background/Aim: This phase II trial evaluated the efficacy and safety of neoadjuvant nab-paclitaxel plus cyclophosphamide (CPA) plus trastuzumab (AbraC-HER) in patients with early HER2-positive breast cancer. Patients and Methods: This was a single-arm, open-label, single-center prospective phase II study. The primary endpoint was pathological complete response rate (pCR rate). The secondary endpoints were clinical antitumor efficacy and the frequency and severity of adverse events. Results: Fifty-nine patients were enrolled in this study. pCR (ypT0/is ypN0) was achieved in 29 patients (49%). The overall response rate was 88.1% (52/59) in all patients. Dose reductions because of adverse events occurred in 3 patients (5.1%) and relative dose intensity was 98%. Compared to Abra-HER, AbraC-HER induced fewer adverse effects. Conclusion: Treatment with nab-paclitaxel plus CPA plus trastuzumab was tolerable and effective with a high pCR rate. This AbraC-HER neoadjuvant therapy may be a feasible new treatment option for patients with early HER2-positive breast cancer. ER -