RT Journal Article SR Electronic T1 The Lectin Helix pomatia Agglutinin as a Marker of Metastases - Clinical and Experimental Studies JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1829 OP 1830 VO 25 IS 3A A1 UDO SCHUMACHER A1 SUSAN A. BROOKS A1 JANOS MESTER YR 2005 UL http://ar.iiarjournals.org/content/25/3A/1829.abstract AB The prognosis for the majority of patients suffering from a solid neoplasm remains bleak, due to the fact that most cancers have already formed metastases at distant sites. Any progress in cancer therapy will, therefore, depend on the understanding of the metastatic cascade and therapies derived from this understanding. The development of clinically relevant models of metastases, using lectin-defined human cancer cell lines and severe combined immunodeficient (SCID) mice, is described. In conjunction with modern imaging techniques, these models will help to elucidate the molecular mechanisms governing the metastatic spread of tumours.