RT Journal Article
SR Electronic
T1 Small Cell Carcinoma of the Endometrium: Light Microscopic and Immunohistochemical Study of a Case
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1823
OP 1825
VO 25
IS 3A
A1 STACHS, ANGRIT
A1 MAKOVITZKY, JOSEPH
A1 BRIESE, VOLKER
YR 2005
UL http://ar.iiarjournals.org/content/25/3A/1823.abstract
AB Small cell carcinoma of the endometrium is extremely rare. The clinical behaviour of this tumour is usually very aggressive. The histopathological distinction of endometrial small cell neuroendocrine carcinoma from mesodermal mixed tumours has important prognostic and therapeutic implications. The case of a 62-year-old white female suffering from postmenopausal bleeding is presented. Macroscopic examination revealed a bulky intraluminal mass with infiltration of more than half of the myometrial wall. In H&E-stained sections atypical small tumour cells revealing neuroendocrine features were found. Immunohistochemical evidence of neuroendocrine differentiation was demonstrated using the markers neuron-specific enolase and synaptophysin. The patient died three months after diagnosis.