RT Journal Article
SR Electronic
T1 Involvement of Proinflammatory Cytokines IL-1β and IL-6 in Progression of Human Gastric Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 709
OP 713
VO 25
IS 2A
A1 KAI, HIROHISA
A1 KITADAI, YASUHIKO
A1 KODAMA, MICHIYO
A1 CHO, SONGDE
A1 KURODA, TSUYOSHI
A1 ITO, MASANORI
A1 TANAKA, SHINJI
A1 OHMOTO, YASUKAZU
A1 CHAYAMA, KAZUAKI
YR 2005
UL http://ar.iiarjournals.org/content/25/2A/709.abstract
AB Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma. Materials and Methods: We measured tissue concentrations of the proinflammatory cytokines interleukin (IL)-1β and IL-6 in gastric carcinoma and investigated the correlation between the levels of these cytokines and clinicopathological features. Biopsy specimens of tumors or adjacent normal mucosa were obtained from 42 Japanese patients with gastric carcinoma. Tissue levels of IL-1β and IL-6 were measured by enzyme-linked immunosorbent assay. Results: IL-1β levels were significantly higher in the neoplasm than in the corresponding normal mucosa. The IL-6 levels in the neoplasm correlated significantly with the depth of invasion and lymphatic invasion. High levels of IL-1β and IL-6 were characteristic of non-scirrhous type gastric carcinoma. Conclusion: These results suggest that IL-1β and IL-6 are involved in the growth and progression of human gastric carcinoma. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved