PT  - JOURNAL ARTICLE
AU  - NORIFUMI HARIMOTO
AU  - KOUKI HOSHINO
AU  - RYO MURANUSHI
AU  - KEI HAGIWARA
AU  - TAKAHIRO YAMANAKA
AU  - NORIHIRO ISHII
AU  - MARIKO TSUKAGOSHI
AU  - TAKAMICHI IGARASHI
AU  - HIROSHI TANAKA
AU  - AKIRA WATANABE
AU  - NORIO KUBO
AU  - KENICHIROU ARAKI
AU  - HIROYASU TOMONAGA
AU  - TETSUYA HIGUCHI
AU  - YOSHITO TSUSHIMA
AU  - KEN SHIRABE
TI  - Impact of Metabolic Parameters of <sup>18</sup>F-Fluorodeoxyglucose Positron-emission Tomography After Hepatic Resection in Patients With Intrahepatic Cholangiocarcinoma
AID  - 10.21873/anticanres.13201
DP  - 2019 Feb 01
TA  - Anticancer Research
PG  - 971--977
VI  - 39
IP  - 2
4099  - http://ar.iiarjournals.org/content/39/2/971.short
4100  - http://ar.iiarjournals.org/content/39/2/971.full
SO  - Anticancer Res2019 Feb 01; 39
AB  - Background: The aim of this study was to identify the prognostic impact of metabolic parameters of 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) in patients with intrahepatic cholangiocarcinoma (IHCC) undergoing hepatic resection. Patients and Methods: Twenty-four patients with IHCC who underwent surgical resection were enrolled and 18F-FDG PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured, as well as overall and recurrence-free survival. Results: High TLG was significantly associated with large tumor size and high carbohydrate antigen 19-9 level. Patients with high SUVmax, high MTV or high TLG had a significantly worse prognosis regarding both overall and recurrence-free survival than those with low SUVmax, low MTV and low TLG, respectively. Multivariate Cox proportional hazards analysis identified that high TLG significantly influenced both overall and recurrence-free survival. Conclusion: Preoperative assessment of TLG by 18F-FDG PET might be a useful prognostic predictor after hepatic resection in patients with IHCC.