RT Journal Article
SR Electronic
T1 The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3401
OP 3407
DO 10.21873/anticanres.15127
VO 41
IS 7
A1 JUNKI FUJITA
A1 MASANOBU NAKAJIMA
A1 HIROTO MUROI
A1 MAIKO KIKUCHI
A1 KEISUKE IHARA
A1 TAKESHI YAMAGUCHI
A1 MASATOSHI NAKAGAWA
A1 SHINJI MORITA
A1 TAKATOSHI NAKAMURA
A1 TAKASHI TSUCHIOKA
A1 KAZUYUKI KOJIMA
YR 2021
UL http://ar.iiarjournals.org/content/41/7/3401.abstract
AB Background/Aim: Plakophilin 1 (PKP1) expression is inversely related to cancer grade. This study aimed to evaluate whether PKP1 is a prognostic marker for esophageal cancer (EC). Materials and Methods: We tested immunohistochemically for PKP1 in squamous cell carcinoma EC specimens from 99 patients, including cytoplasmic (C), membrane (M), and nuclear (N) cellular areas, and analyzed their relationships with clinicopathological factors. Results: PKP1stains were stratified into strong and weak for all three cellular areas. Staining was inversely related to tumor depth (C: p=0.002, M: p=0.00007, N: p=0.02), lymph node metastasis (C: p=0.003, M: p=0.001, N: p=0.004) and pathological stage (C: p=0.0004, M: p=0.0001, N: p=0.006). Cytoplasmic and membrane staining were inversely related to vessel invasion. Patients with strong C stain had a better overall survival than those with weak C stains (p=0.01). Disease-free survival of patients with strong M stains was better than that of those with weak staining (p=0.01). Conclusion: Cytoplasmic and membrane PKP1 expression is a possible prognostic marker for EC.