TY - JOUR T1 - The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer JF - Anticancer Research JO - Anticancer Res SP - 3401 LP - 3407 DO - 10.21873/anticanres.15127 VL - 41 IS - 7 AU - JUNKI FUJITA AU - MASANOBU NAKAJIMA AU - HIROTO MUROI AU - MAIKO KIKUCHI AU - KEISUKE IHARA AU - TAKESHI YAMAGUCHI AU - MASATOSHI NAKAGAWA AU - SHINJI MORITA AU - TAKATOSHI NAKAMURA AU - TAKASHI TSUCHIOKA AU - KAZUYUKI KOJIMA Y1 - 2021/07/01 UR - http://ar.iiarjournals.org/content/41/7/3401.abstract N2 - Background/Aim: Plakophilin 1 (PKP1) expression is inversely related to cancer grade. This study aimed to evaluate whether PKP1 is a prognostic marker for esophageal cancer (EC). Materials and Methods: We tested immunohistochemically for PKP1 in squamous cell carcinoma EC specimens from 99 patients, including cytoplasmic (C), membrane (M), and nuclear (N) cellular areas, and analyzed their relationships with clinicopathological factors. Results: PKP1stains were stratified into strong and weak for all three cellular areas. Staining was inversely related to tumor depth (C: p=0.002, M: p=0.00007, N: p=0.02), lymph node metastasis (C: p=0.003, M: p=0.001, N: p=0.004) and pathological stage (C: p=0.0004, M: p=0.0001, N: p=0.006). Cytoplasmic and membrane staining were inversely related to vessel invasion. Patients with strong C stain had a better overall survival than those with weak C stains (p=0.01). Disease-free survival of patients with strong M stains was better than that of those with weak staining (p=0.01). Conclusion: Cytoplasmic and membrane PKP1 expression is a possible prognostic marker for EC. ER -