RT Journal Article SR Electronic T1 Cytokine-based Cancer Immunotherapy: Challenges and Opportunities for IL-10 JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3247 OP 3252 DO 10.21873/anticanres.15110 VO 41 IS 7 A1 KATHRINE S. RALLIS A1 AMBER E. CORRIGAN A1 HASHIM DADAH A1 ALAN MATHEW GEORGE A1 SUMIRAT M. KESHWARA A1 MICHAIL SIDERIS A1 BERNADETT SZABADOS YR 2021 UL http://ar.iiarjournals.org/content/41/7/3247.abstract AB Cancer immunotherapy is an evolving field of research. Cytokines have been conceptualized as an anticancer therapy for longer than most other cancer immunotherapy modalities. Yet, to date, only two cytokines are FDA-approved: IFN-α and IL-2. Despite the initial breakthrough, both agents have been superseded by other, more efficacious agents such as immune checkpoint inhibitors. Several issues persist with cytokine-based cancer therapies; these are broadly categorised into a) high toxicity and b) low efficacy. Despite the only moderate benefits with early cytokine-based cancer therapies, advances in molecular engineering, genomics, and molecular analysis hold promise to optimise and reinstate cytokine-based therapies in future clinical practice. This review considers five important concepts for the successful clinical application of cytokine-based cancer therapies including: (i) improving pharmacokinetics and pharmacodynamics, (ii) improving local administration strategies, (iii) understanding context-dependent interactions in the tumour-microenvironment, (iv) elucidating the role of genetic polymorphisms, and (v) optimising combination therapies. IL-10 has been the focus of attention in recent years and is discussed herein as an example.