<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">HANTSCHMANN, PEER</style></author><author><style face="normal" font="default" size="100%">JESCHKE, UDO</style></author><author><style face="normal" font="default" size="100%">FRIESE, KLAUS</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">TGF-α, c-erbB-2 Expression and Neoangiogenesis in Vulvar Squamous Cell Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1731-1737</style></pages><volume><style face="normal" font="default" size="100%">25</style></volume><issue><style face="normal" font="default" size="100%">3A</style></issue><abstract><style  face="normal" font="default" size="100%">Background: TGFα and c-erbB-2 are important mediators of tumor neoangiogenesis linked to the epidermal growth factor receptor. Thus, we analyzed TGFα c-erbB-2 and tumor neoangiogenesis in vulvar carcinoma and determined their prognostic significance. Patients and Methods: Seventy-five carcinomas were evaluated for histological parameters. Tumors were stained immunohistologically for TGFα, c-erbB-2 and factor VIII antigen. Results were analyzed statistically by Ã2-test, Kaplan-Meier survival curves and log-rank-test. Results: Sixty-five % of the carcinomas were positive for TGFα in &gt;50% of the tumor cells. C-erbB-2 overexpression occurred in 47% of the tumors, but there was frequently a high cytoplasmatic staining. Twenty-nine % showed high microvessel densitiy. These tumors were more likely to have vascular space involvement (p=0.02). In carcinomas with TGFα expression in &gt;50% of the tumor cells, microvessel density was increased (p=0.05). Overall and disease-free survival tended to be reduced for tumors with high TGFα expression and microvessel density, but differences were not significant. Conclusion: Tumor neoangiogenesis is an important event in vulvar carcinogenesis which is related to the expression of growth factors.</style></abstract></record></records></xml>