TY - JOUR T1 - Proton Beam Therapy for Local Recurrence of Rectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 3589 LP - 3595 DO - 10.21873/anticanres.15147 VL - 41 IS - 7 AU - YUICHI HIROSHIMA AU - HITOSHI ISHIKAWA AU - MOTOHIRO MURAKAMI AU - MASATOSHI NAKAMURA AU - SHOSEI SHIMIZU AU - TSUYOSHI ENOMOTO AU - TATSUYA ODA AU - MASASHI MIZUMOTO AU - KEI NAKAI AU - TOSHIYUKI OKUMURA AU - HIDEYUKI SAKURAI Y1 - 2021/07/01 UR - http://ar.iiarjournals.org/content/41/7/3589.abstract N2 - Background/Aim: Curing local recurrence of rectal cancer (LRRC) is difficult with conventional photon radiotherapy. Proton beam therapy (PBT) on the other hand, has unique physical characteristics that permit higher doses to LRRC while minimizing side effects on surrounding organs. However, the efficacy of PBT on controlling rectal cancer recurrence has not yet been reported. This study aimed to evaluate clinical outcomes and toxicities of PBT for LRRC. Patients and Methods: Clinical outcomes were retrospectively evaluated for 12 patients with 13 total lesions that had received PBT for LRRC at our institute. Results: The median follow-up period from the initiation of PBT was 42.9 months. The 3-year local control, progression-free survival and overall survival rates were 80.2%, 12.1% and 71.3%, respectively. Median survival time was 67.1 months. There were no severe acute or late adverse events. Conclusion: PBT could be a safe and effective treatment method for LRRC. ER -