RT Journal Article
SR Electronic
T1 Pretreatment Absolute Lymphocyte Count and Neutrophil-to-lymphocyte Ratio Are Prognostic Factors for Stage III Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3625
OP 3634
DO 10.21873/anticanres.15151
VO 41
IS 7
A1 KOSHO YAMANOUCHI
A1 SHIGETO MAEDA
A1 DAIKI TAKEI
A1 YOICHI KOGA
A1 MANPEI YAMASHITA
A1 TAKASHI HAMADA
A1 TAKANORI HIRAYAMA
A1 AKIRA YONEDA
A1 TAKAYUKI TOKUNAGA
A1 HIROAKI TAKESHITA
A1 TAMOTSU KUROKI
YR 2021
UL http://ar.iiarjournals.org/content/41/7/3625.abstract
AB Background/Aim: Stage III breast cancer comprises a broad spectrum of disease, including the extent of supraclavicular/internal mammary lymph node metastasis. In this study, we evaluated the usefulness of the absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) in predicting the prognosis of patients with stage III breast cancer. Patients and Methods: Seventy-five patients with stage III breast cancer who underwent surgery were included. We compared their clinicopathological factors according to the presence or not of supraclavicular/internal mammary lymph node metastasis, and pretreatment ALC or NLR. Results: Patients with metastasis of the studied lymph nodes had a poorer prognosis in comparison to those without metastasis. In patients without these types of lymph node metastasis, both the ALC and NLR were predictive factors for relapse-free and overall survival. Among these patients, those with a low ALC or high NLR had recurrence-free and overall survival comparable to those of patients with supraclavicular/internal mammary lymph node metastasis. Conclusion: Pretreatment ALC and NLR were prognostic factors for patients with stage III breast cancer.