TY - JOUR T1 - Calcipotriol Enhances Efficacy of Imatinib and Nilotinib on Cells Derived from Plexiform Neurofibroma JF - Anticancer Research JO - Anticancer Res SP - 3293 LP - 3298 DO - 10.21873/anticanres.15116 VL - 41 IS - 7 AU - YAO ZHAO AU - MING YAN AU - VICTOR MAUTNER AU - RALF SMEETS AU - MARTIN GOSAU AU - LAN KLUWE AU - REINHARD E. FRIEDRICH Y1 - 2021/07/01 UR - http://ar.iiarjournals.org/content/41/7/3293.abstract N2 - Background/Aim: Plexiform neurofibromas (PNFs) are benign tumors composed mainly of tumorous Schwann cells and non-tumorous fibroblasts. This study examined the possible enhancing effect of vitamin D on the efficacy of drugs used for the treatment of PNF in vitro. Materials and Methods: Paired Schwann cells and fibroblasts were cultured from 10 PNFs and treated with imatinib and nilotinib in the absence and presence of calcipotriol, an analogue of the active metabolite of vitamin D. IC50 values for cell proliferation were calculated. Results: Calcipotriol reduced the IC50 of the two drugs in both tumorous Schwann cells and non-tumorous fibroblasts by 40 to 45%. Conclusion: Calcipotriol enhanced the efficacy of imatinib and nilotinib on PNF-derived cells in vitro, though rather non-specifically. Nevertheless, sustaining vitamin D at 100-200 nM, the physiological range, may be beneficial for reducing the dose of drugs without scarifying efficacy. ER -