RT Journal Article
SR Electronic
T1 Crypts in Asymmetric Fission in Endoscopic Biopsies from Swedish Patients With Inflammatory Bowel Disease
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3511
OP 3517
DO 10.21873/anticanres.15138
VO 41
IS 7
A1 CARLOS A. RUBIO
A1 PETER T. SCHMIDT
YR 2021
UL http://ar.iiarjournals.org/content/41/7/3511.abstract
AB Background/Aim: We previously found crypts in symmetric fission (CSF) and in asymmetric fission (CAF) in colectomy-specimens with ulcerative colitis. We now analyzed CSF and CAF (CSAF) in biopsies from 80 patients with inflammatory bowel disease (IBD) without dysplasia or carcinoma. Patients and Methods: One unselected double-biopsy from affected endoscopic areas was investigated in the 80 cases. Results: A total of 353 crypts in fission were found. The median number of CAF/biopsy was 3.7 and for CSF/biopsy, 0.7 (p<0.00001). Conclusion: CSAF often occur in unselected biopsies from patients with IBD. Whereas the increased frequency of CSF might mirror a compensatory mechanism of crypt production in areas occupied by inflammation, CAF reflects a pathological aberration of cryptogenesis, probably generated by somatic mutations. The biological significance of CAF in IBD without dysplasia or carcinoma, deserves to be further investigated.