PT  - JOURNAL ARTICLE
AU  - CARLOS A. RUBIO
AU  - PETER T. SCHMIDT
TI  - Crypts in Asymmetric Fission in Endoscopic Biopsies from Swedish Patients With Inflammatory Bowel Disease
AID  - 10.21873/anticanres.15138
DP  - 2021 Jul 01
TA  - Anticancer Research
PG  - 3511--3517
VI  - 41
IP  - 7
4099  - http://ar.iiarjournals.org/content/41/7/3511.short
4100  - http://ar.iiarjournals.org/content/41/7/3511.full
SO  - Anticancer Res2021 Jul 01; 41
AB  - Background/Aim: We previously found crypts in symmetric fission (CSF) and in asymmetric fission (CAF) in colectomy-specimens with ulcerative colitis. We now analyzed CSF and CAF (CSAF) in biopsies from 80 patients with inflammatory bowel disease (IBD) without dysplasia or carcinoma. Patients and Methods: One unselected double-biopsy from affected endoscopic areas was investigated in the 80 cases. Results: A total of 353 crypts in fission were found. The median number of CAF/biopsy was 3.7 and for CSF/biopsy, 0.7 (p<0.00001). Conclusion: CSAF often occur in unselected biopsies from patients with IBD. Whereas the increased frequency of CSF might mirror a compensatory mechanism of crypt production in areas occupied by inflammation, CAF reflects a pathological aberration of cryptogenesis, probably generated by somatic mutations. The biological significance of CAF in IBD without dysplasia or carcinoma, deserves to be further investigated.