RT Journal Article
SR Electronic
T1 Clinical Impact of Postoperative Vitamin D Deficiency on the Recurrence of Colon Cancer After Curative Surgical Resection
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3683
OP 3688
DO 10.21873/anticanres.15159
VO 41
IS 7
A1 JUHYUNG KIM
A1 DONG WON BAEK
A1 JIN HO BAEK
A1 BYUNG WOOG KANG
A1 SEUNG HO SONG
A1 HYE JIN KIM
A1 SOO YEUN PARK
A1 JUN SEOK PARK
A1 GYU-SEOG CHOI
A1 JONG GWANG KIM
YR 2021
UL http://ar.iiarjournals.org/content/41/7/3683.abstract
AB Background/Aim: There are no clinically significant cutoff values of serum vitamin D levels and time points to predict the prognosis of colon cancer, particularly in patients who underwent curative surgical resection. Patients and Methods: We retrospectively analyzed serum vitamin D levels in 795 patients with stages I to III colon cancer who underwent curative surgical resection. Results: Patients with vitamin D levels below 12 ng/ml at one year after surgical resection demonstrated a significantly reduced disease-free survival (DFS) than those who did not have vitamin D deficiency (p=0.01). In the multivariate analysis, an age of 70 years or older [hazard ratio (HR)=1.992; p=0.001], pathologic stage (HR=3.739; p<0.001), and vitamin D deficiency (less than 12 ng/ml) at one year after surgery (HR=0.563; p=0.020) were factors unfavorably influencing DFS. Conclusion: In patients with stages I to III of colon cancer, vitamin D deficiency at one year after surgical resection was associated with increased disease relapse.