PT - JOURNAL ARTICLE AU - JUHYUNG KIM AU - DONG WON BAEK AU - JIN HO BAEK AU - BYUNG WOOG KANG AU - SEUNG HO SONG AU - HYE JIN KIM AU - SOO YEUN PARK AU - JUN SEOK PARK AU - GYU-SEOG CHOI AU - JONG GWANG KIM TI - Clinical Impact of Postoperative Vitamin D Deficiency on the Recurrence of Colon Cancer After Curative Surgical Resection AID - 10.21873/anticanres.15159 DP - 2021 Jul 01 TA - Anticancer Research PG - 3683--3688 VI - 41 IP - 7 4099 - http://ar.iiarjournals.org/content/41/7/3683.short 4100 - http://ar.iiarjournals.org/content/41/7/3683.full SO - Anticancer Res2021 Jul 01; 41 AB - Background/Aim: There are no clinically significant cutoff values of serum vitamin D levels and time points to predict the prognosis of colon cancer, particularly in patients who underwent curative surgical resection. Patients and Methods: We retrospectively analyzed serum vitamin D levels in 795 patients with stages I to III colon cancer who underwent curative surgical resection. Results: Patients with vitamin D levels below 12 ng/ml at one year after surgical resection demonstrated a significantly reduced disease-free survival (DFS) than those who did not have vitamin D deficiency (p=0.01). In the multivariate analysis, an age of 70 years or older [hazard ratio (HR)=1.992; p=0.001], pathologic stage (HR=3.739; p<0.001), and vitamin D deficiency (less than 12 ng/ml) at one year after surgery (HR=0.563; p=0.020) were factors unfavorably influencing DFS. Conclusion: In patients with stages I to III of colon cancer, vitamin D deficiency at one year after surgical resection was associated with increased disease relapse.