@article {KNITTER3499, author = {SEBASTIAN KNITTER and ANDREAS ANDREOU and TOBIAS HOFMANN and SASCHA CHOPRA and CHRISTIAN DENECKE and PETER C. THUSS-PATIENCE and DINO KR{\"O}LL and MARCUS BAHRA and MORITZ SCHMELZLE and JOHANN PRATSCHKE and MATTHIAS BIEBL}, title = {Minimally Invasive Versus Open Ivor-Lewis Esophagectomy for Esophageal Cancer or Cancer of the Gastroesophageal Junction: Comparison of Postoperative Outcomes and Long-term Survival Using Propensity Score Matching Analysis}, volume = {41}, number = {7}, pages = {3499--3510}, year = {2021}, doi = {10.21873/anticanres.15137}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Esophagectomy is crucial for achieving long-term survival in patients with esophageal cancer, while being associated with a significant risk of complications. Aiming to reduce invasiveness and morbidity, total minimal-invasive esophagectomy (MIE) has been gradually implemented worldwide. The aim of the study was to compare MIE to open Ivor-Lewis esophagectomy (OE) for esophageal cancer or cancer of the gastroesophageal junction (GEJ), in terms of postoperative and oncological outcomes. Patients and Methods: Clinicopathological data of patients undergoing oncologic transthoracic esophagectomy (Ivor Lewis procedure) between 2010 and 2019 were assessed. Postoperative outcomes and long-term survival of patients undergoing OE were compared to those after MIE using 1:1 propensity score matching. Results: After excluding hybrid and robotic procedures, 90 patients who underwent MIE were compared with a matched cohort of 90 patients who underwent OE. MIE was associated with lower major postoperative morbidity (31\% vs. 46\%, p=0.046) and lower 90-day mortality (2\% vs. 12\%, p=0.010) compared to OE. MIE showed non-inferior 3-year overall (65\% vs. 52\%, p=0.019) and comparable disease-free survival rates (49\% vs. 51\%, p=0.851) in comparison to OE. Conclusion: Our data suggest that MIE should be preferably performed in patients with esophageal cancer or cancer of the GEJ.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/41/7/3499}, eprint = {https://ar.iiarjournals.org/content/41/7/3499.full.pdf}, journal = {Anticancer Research} }