RT Journal Article
SR Electronic
T1 Expression of Her2/neu, Steroid Receptors (ER and PR), Ki67 and p53 in Invasive Mammary Ductal Carcinoma Associated with Ductal Carcinoma <em>In Situ</em> (DCIS) <em>Versus</em> Invasive Breast Cancer Alone
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1719
OP 1723
VO 25
IS 3A
A1 IOANNIS MYLONAS
A1 JOSEF MAKOVITZKY
A1 UDO JESCHKE
A1 VOLKER BRIESE
A1 KLAUS FRIESE
A1 BERND GERBER
YR 2005
UL http://ar.iiarjournals.org/content/25/3A/1719.abstract
AB Aims: (a) To assess the expression patterns of HER2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive ductal cancer (IDC) and IDC associated with carcinoma in situ (IDC/DCIS) and (b) to determine if there is a differential expression of these molecular markers between IDC and IDC/DCIS. Materials and Methods: Paraffin-fixed breast cancer samples, diagnosed with only one histological invasive tumor (IDC (n=130), and IDC/DCIS (n=36) were analyzed by immunohistochemical means. The non-parametric Mann-Whitney and χ2 tests were used to evaluate any statistical differences between different groups. Significance was assumed at p&lt;0.05. Results: A significant increase of the tumor grading was observed between IDC and IDC/DCIS (p&lt;0.05). Her2/neu amplification was demonstrated in 49.6% of IDC compared to 31% of IDC/DCIS (p&lt;0.05). ER expression showed no statistical differences between IDC and IDC/DCIS. The PR expression was demonstrated in 71% of IDC with significantly lower intensity than IDC/DCIS (p&lt;0.05). The Ki67 expression was significantly higher (p&lt;0.05) in IDC cases (64%) versus IDC/DCIS (49.7%). No differences were observed between IDC and IDC/DCIS for p53 expression. Conclusion: We demonstrated significantly different expression patterns of Her2/neu, PR and Ki67 in IDC versus IDC/DCIS. Since these molecular markers play important roles in carcinogenesis and tumor progression, IDC/DCIS could be an important subtype of mammary invasive ductal cancer. Differences in expression of the evaluated markers might suggest a higher malignant potential of invasive carcinomas alone. The lower expression of Her2/neu and Ki67 in IDC/DCIS could implicate a less malignant behavior compared to a differentiated IDC. Additionally, these results might suggest that DCIS might be a malignant preform and the interaction with neoplastic tissue could result in an aggressive type of invasive tumor.