RT Journal Article SR Electronic T1 Palliative Local Radiotherapy for Advanced Squamous Cell Carcinoma of the Head-and-Neck: Prognostic Factors of Survival JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3205 OP 3210 DO 10.21873/anticanres.15107 VO 41 IS 6 A1 CHRISTIAN STAACKMANN A1 JULIKA RIBBAT-IDEL A1 SVEN PERNER A1 CHRISTIAN IDEL A1 KARL L. BRUCHHAGE A1 SAMER G. HAKIM A1 STEVEN E. SCHILD A1 DIRK RADES YR 2021 UL http://ar.iiarjournals.org/content/41/6/3205.abstract AB Background/Aim: A considerable number of patients with advanced head-and-neck cancer (SCCHN) receive palliative radiotherapy. This study aimed to identify prognostic factors for survival to facilitate personalized treatment for these patients. Patients and Methods: Ninety-two patients receiving palliative radiotherapy for SCCHN were retrospectively analyzed. Fourteen characteristics were evaluated for survival including age, gender, performance score, pre-radiotherapy hemoglobin, tumor site and stage, histologic grade, p16-status, equivalent dose in 2 Gy-fractions (EQD2), completion of radiotherapy, upfront surgery and systemic therapy. Results: On univariate analysis, improved survival was significantly associated with pre-radiotherapy hemoglobin ≥12 g/dl (p=0.003), EQD2 >42.3 Gy (p=0.003) and completion of radiotherapy (p<0.001). In the multivariate analysis, hemoglobin levels remained significant (p=0.024). Trends were found for EQD2 (p=0.057) and completion of radiotherapy (p=0.093). Conclusion: Prognostic factors for survival were identified that can facilitate treatment personalization. The fact that higher EQD2 and completion of radiotherapy were associated with improved survival demonstrates the importance of close monitoring and care of these patients during radiotherapy.