TY - JOUR T1 - Palliative Local Radiotherapy for Advanced Squamous Cell Carcinoma of the Head-and-Neck: Prognostic Factors of Survival JF - Anticancer Research JO - Anticancer Res SP - 3205 LP - 3210 DO - 10.21873/anticanres.15107 VL - 41 IS - 6 AU - CHRISTIAN STAACKMANN AU - JULIKA RIBBAT-IDEL AU - SVEN PERNER AU - CHRISTIAN IDEL AU - KARL L. BRUCHHAGE AU - SAMER G. HAKIM AU - STEVEN E. SCHILD AU - DIRK RADES Y1 - 2021/06/01 UR - http://ar.iiarjournals.org/content/41/6/3205.abstract N2 - Background/Aim: A considerable number of patients with advanced head-and-neck cancer (SCCHN) receive palliative radiotherapy. This study aimed to identify prognostic factors for survival to facilitate personalized treatment for these patients. Patients and Methods: Ninety-two patients receiving palliative radiotherapy for SCCHN were retrospectively analyzed. Fourteen characteristics were evaluated for survival including age, gender, performance score, pre-radiotherapy hemoglobin, tumor site and stage, histologic grade, p16-status, equivalent dose in 2 Gy-fractions (EQD2), completion of radiotherapy, upfront surgery and systemic therapy. Results: On univariate analysis, improved survival was significantly associated with pre-radiotherapy hemoglobin ≥12 g/dl (p=0.003), EQD2 >42.3 Gy (p=0.003) and completion of radiotherapy (p<0.001). In the multivariate analysis, hemoglobin levels remained significant (p=0.024). Trends were found for EQD2 (p=0.057) and completion of radiotherapy (p=0.093). Conclusion: Prognostic factors for survival were identified that can facilitate treatment personalization. The fact that higher EQD2 and completion of radiotherapy were associated with improved survival demonstrates the importance of close monitoring and care of these patients during radiotherapy. ER -