RT Journal Article
SR Electronic
T1 Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3067
OP 3073
DO 10.21873/anticanres.15090
VO 41
IS 6
A1 MANUEL M. GARRIDO
A1 RUY M. RIBEIRO
A1 KIMBERLY KRÜGER
A1 LUÍS C. PINHEIRO
A1 JOÃO T. GUIMARÃES
A1 STEFAN HOLDENRIEDER
YR 2021
UL http://ar.iiarjournals.org/content/41/6/3067.abstract
AB Background/Aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and Methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity. Results: Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines. Conclusion: In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.