PT  - JOURNAL ARTICLE
AU  - MANUEL M. GARRIDO
AU  - RUY M. RIBEIRO
AU  - KIMBERLY KRÜGER
AU  - LUÍS C. PINHEIRO
AU  - JOÃO T. GUIMARÃES
AU  - STEFAN HOLDENRIEDER
TI  - Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
AID  - 10.21873/anticanres.15090
DP  - 2021 Jun 01
TA  - Anticancer Research
PG  - 3067--3073
VI  - 41
IP  - 6
4099  - http://ar.iiarjournals.org/content/41/6/3067.short
4100  - http://ar.iiarjournals.org/content/41/6/3067.full
SO  - Anticancer Res2021 Jun 01; 41
AB  - Background/Aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and Methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity. Results: Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines. Conclusion: In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.