TY - JOUR T1 - Impact of Topoisomerases Complex Deregulation on Head and Neck Carcinoma Genomic Instability JF - Anticancer Research JO - Anticancer Res SP - 2773 LP - 2779 DO - 10.21873/anticanres.15058 VL - 41 IS - 6 AU - EFTHYMIOS KYRODIMOS AU - ARISTEIDIS CHRYSOVERGIS AU - NICHOLAS MASTRONIKOLIS AU - EVANGELOS TSIAMBAS AU - VASILEIOS RAGOS AU - DIMITRIOS PESCHOS AU - DESPOINA SPYROPOULOY AU - PAVLOS PANTOS AU - ATHANASIOS NIOTIS AU - VASILEIOS PAPANIKOLAOU Y1 - 2021/06/01 UR - http://ar.iiarjournals.org/content/41/6/2773.abstract N2 - Head and neck carcinoma (HNC) comprises a variety of pathological entities. Among them, squamous cell carcinoma (SCC) is histo-pathologically prominent. Specific malignancies, such as nasopharyngeal carcinoma (NPC) arise also from the same anatomical region. In all of them, genomic instability (GI) is implicated not only in the early stages of epithelial malignant transformation, but also in the aggressiveness of the corresponding phenotypes. Among the molecules that are frequently deregulated in solid malignancies including HNCs, topoisomerases (Topo) are of increased significance due to their involvement in DNA topological, structural, and functional stability. The main members are Topo I (20q11), Topo II alpha (17q21) and Topo IIb (3p24). In the current article, we describe the mechanisms of Topo I and Topo IIa deregulation leading to GI in a variety of HNCs. Furthermore, novel data regarding the corresponding targeted therapeutic strategies are presented. ER -