TY - JOUR T1 - Plan Complexity and Delivery Accuracy of Knowledge-based Volumetric Modulated Arc Therapy Plans with Single Optimization for Oropharyngeal Cancer JF - Anticancer Research JO - Anticancer Res SP - 2925 LP - 2931 DO - 10.21873/anticanres.15074 VL - 41 IS - 6 AU - KATSUYA OKUHATA AU - HAJIME MONZEN AU - MIKOTO TAMURA AU - KENJI MATSUMOTO AU - MASAKAZU OTSUKA AU - KAZUKI KUBO AU - YOSHIHIRO UEDA AU - TAKUYA UEHARA AU - HIROSHI DOI AU - KAZUKI ISHIKAWA AU - YASUMASA NISHIMURA Y1 - 2021/06/01 UR - http://ar.iiarjournals.org/content/41/6/2925.abstract N2 - Background/Aim: We investigated the plan complexity of volumetric modulated arc therapy (VMAT) with knowledge-based plan (KBP) for oropharyngeal cancer (OPC) with a single optimization and whether it could be used clinically. Materials and Methods: KBP model was configured using 55 consecutive OPC and nasopharyngeal cancer plans. Plan complexity as a characteristic of multileaf collimator (MLC) motion and γ pass rate (2%/2 mm criterion) were compared between clinical manual plan (CMP) and KBP for other 10 plans. Results: Plan complexity metrics that had significant differences (p<0.05) (CMP vs. KBP), were mean lateral displacement of MLC from central axis (15.82 mm vs. 18.90 mm), proportions of MLC aperture sizes of ≤5 mm (0.14 vs. 0.11), ≤10 mm (0.24 vs. 0.19), and ≤20 mm (0.41 vs. 0.34), and monitor units (578.68 vs. 505.04). The γ pass rate was 91.3% vs. 93.3%. Conclusion: Single optimized KBP for OPC had simple plan complexity features and comparable delivery accuracy to CMP, and could be clinically applied. ER -