RT Journal Article
SR Electronic
T1 Plan Complexity and Delivery Accuracy of Knowledge-based Volumetric Modulated Arc Therapy Plans with Single Optimization for Oropharyngeal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2925
OP 2931
DO 10.21873/anticanres.15074
VO 41
IS 6
A1 KATSUYA OKUHATA
A1 HAJIME MONZEN
A1 MIKOTO TAMURA
A1 KENJI MATSUMOTO
A1 MASAKAZU OTSUKA
A1 KAZUKI KUBO
A1 YOSHIHIRO UEDA
A1 TAKUYA UEHARA
A1 HIROSHI DOI
A1 KAZUKI ISHIKAWA
A1 YASUMASA NISHIMURA
YR 2021
UL http://ar.iiarjournals.org/content/41/6/2925.abstract
AB Background/Aim: We investigated the plan complexity of volumetric modulated arc therapy (VMAT) with knowledge-based plan (KBP) for oropharyngeal cancer (OPC) with a single optimization and whether it could be used clinically. Materials and Methods: KBP model was configured using 55 consecutive OPC and nasopharyngeal cancer plans. Plan complexity as a characteristic of multileaf collimator (MLC) motion and γ pass rate (2%/2 mm criterion) were compared between clinical manual plan (CMP) and KBP for other 10 plans. Results: Plan complexity metrics that had significant differences (p<0.05) (CMP vs. KBP), were mean lateral displacement of MLC from central axis (15.82 mm vs. 18.90 mm), proportions of MLC aperture sizes of ≤5 mm (0.14 vs. 0.11), ≤10 mm (0.24 vs. 0.19), and ≤20 mm (0.41 vs. 0.34), and monitor units (578.68 vs. 505.04). The γ pass rate was 91.3% vs. 93.3%. Conclusion: Single optimized KBP for OPC had simple plan complexity features and comparable delivery accuracy to CMP, and could be clinically applied.