TY - JOUR T1 - Proteomic Analysis of Malignant Ascites From Patients With Pancreatic Ductal Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 2895 LP - 2900 DO - 10.21873/anticanres.15071 VL - 41 IS - 6 AU - FUMIMASA KITAMURA AU - TATSUNORI MIYATA AU - NORIO UEMURA AU - TOMOYUKI UCHIHARA AU - KATSUNORI IMAI AU - HIROMITSU HAYASHI AU - YO-ICHI YAMASHITA AU - KEISUKE MATSUSAKI AU - TAKATSUGU ISHIMOTO AU - HIDEO BABA Y1 - 2021/06/01 UR - http://ar.iiarjournals.org/content/41/6/2895.abstract N2 - Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor. Research using an innovative research approach is needed to identify effective biomarkers or therapeutic targets for PDAC. We aimed to identify proteins related to the peritoneal dissemination of PDAC. Materials and Methods: We performed proteomic analysis using ascites samples from patients with advanced PDAC and peritoneal dissemination and patients with liver cirrhosis (LC). Proteins specific to PDAC were identified in comparison to the findings for ascites from patients with LC as a control group. Results: In total, 336 proteins were identified in ascites from patients with PDAC. We identified 18 specific proteins in ascites from patients with advanced PDAC. Among these proteins, CD13, lymphatic vessel endothelial hyaluronan receptor 1, ficolin-3, and V-set and immunoglobulin domain containing 4 were the most frequently detected. In addition, these 18 proteins could be classified into four categories: extracellular matrix, immunity, metabolism, and others. Conclusion: The identified proteins could be informative for developing treatment strategies for patients with PDAC and peritoneal dissemination. ER -