TY - JOUR T1 - A Clinicopathological Study of Young-onset Hepatocellular Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2933 LP - 2944 DO - 10.21873/anticanres.15075 VL - 41 IS - 6 AU - KWAN-YUNG AU AU - KRISTY KWAN-SHUEN CHAN AU - REGINA CHEUK-LAM LO Y1 - 2021/06/01 UR - http://ar.iiarjournals.org/content/41/6/2933.abstract N2 - Background/Aim: The aim of this study was to describe the clinicopathological features of hepatocellular carcinoma (HCC) diagnosed at 40 years of age or below. Materials and Methods: Expression of CK19, Glypican-3 and β-catenin was assessed in clinical samples by immunohistochemistry (IHC). IHC expression was correlated with clinicopathological parameters. Hotspot mutations in TP53 gene were analyzed by sequencing. Results: Thirty-six cases were included with a male to female ratio of 3:1. Eighty percent of cases were associated with chronic hepatitis B infection. CK19 and GPC3 were expressed in 61% and 56% of cases, respectively. Only one case demonstrated β-catenin over-expression. TP53 hotspot mutation was identified in 4 cases. Number of tumor nodules, vascular invasion, and preoperative serum AFP level were associated with prognosis. Conclusion: A higher CK19 expression rate was observed in our young-onset HCC cohort, whereas β-catenin pathway activation and TP53 gene mutation events were less frequent. Conventional clinicopathological parameters remain predictors of survival. ER -