RT Journal Article
SR Electronic
T1 HLA-DR and CD74 Expression and the Immune Microenvironment in Renal Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2841
OP 2848
DO 10.21873/anticanres.15065
VO 41
IS 6
A1 YUJI MIURA
A1 TOSHIKI ANAMI
A1 JUNJI YATSUDA
A1 TAKANOBU MOTOSHIMA
A1 SUGURU OKA
A1 KOICHI SUYAMA
A1 NAOKO INOSHITA
A1 KEIICHI KINOWAKI
A1 SHINJI URAKAMI
A1 TOMOMI KAMBA
A1 YOSHIHIRO KOMOHARA
YR 2021
UL http://ar.iiarjournals.org/content/41/6/2841.abstract
AB Background/Aim: Expression of human leukocyte antigen (HLA) class I and II and CD74, which functions as a chaperone of MHC class II, play essential roles in T-cell recognition. The aim of this study was to elucidate the association between the HLAs and CD74, and their correlation with the infiltrated immune cells in renal cell carcinoma (RCC). Materials and Methods: We retrospectively investigated the expression of HLA-A/B/C, HLA-DR, and CD74 in 38 patients with advanced RCC (T3/T4), and evaluated their correlations with CD4 and CD8-positive T-cell infiltration using immunohistochemistry. Results: The expression of HLA-A/B/C, HLA-DR, and CD74 on cancer cells was observed in 37, 20, and 31 patients, respectively. The density of CD8- and CD4-positive T cells showed a positive correlation with HLA-DR expression. The density of CD4-positive lymphocytes was significantly associated with CD74 expression. Conclusion: The expression of HLA-DR, rather than CD74, on cancer cells was potentially associated with the anti-cancer immune microenvironment.