RT Journal Article
SR Electronic
T1 Primary Melanoma of the Female Genital System: A Report of 10 Cases and Review of the Literature
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1567
OP 1574
VO 25
IS 3A
A1 JAHNKE, A.
A1 MAKOVITZKY, J.
A1 BRIESE, V.
YR 2005
UL http://ar.iiarjournals.org/content/25/3A/1567.abstract
AB Background: Primary melanoma of the female genital system are extremely rare (2-3%). Patients and Methods: A retrospective review was undertaken of patients with primary melanoma of the female genital system treated from 1990-2003 at Rostock University Hospital, Germany. Different treatments (sentinel node biopsy, inguinofemoral lymphadenectomy, en bloc resection, adjuvant Interferon-alpha-therapy, adjuvant chemotherapy) are discussed. The complicated classification is reduced to a clinical path for daily use (UICC stage and invasion depth of Breslow, Clark's level and Chung's level). Results: We report on 10 patients, aged 26 to 76 years, with primary melanoma of the female genital tract. Seven women developed a vulvar melanoma and one woman a malignant melanoma of the cutaneous inguinal region, while another 2 women had an unusual primary location of the malignant melanoma, the cervico-vaginal region (n=1) and the left ovary (n=1). Conclusion: Initial surgical modality did not influence long-term survival, but affected disease-free survival significantly.