TY - JOUR T1 - Brainstem Infiltration Predicts Survival in Patients With High-grade Gliomas Treated With Chemoradiotherapy JF - Anticancer Research JO - Anticancer Res SP - 2583 LP - 2589 DO - 10.21873/anticanres.15037 VL - 41 IS - 5 AU - SHIMPEI ANAMI AU - JUNYA FUKAI AU - MIZUKI HAMA AU - AZUSA AWAYA AU - TAKAYA INAGAKI AU - TAKAHIRO CHIBA AU - YASUTAKA NODA AU - YONEHIRO KANEMURA AU - NAOYUKI NAKAO AU - TETSUO SONOMURA Y1 - 2021/05/01 UR - http://ar.iiarjournals.org/content/41/5/2583.abstract N2 - Background/Aim: High-grade gliomas have a poor prognosis despite standard treatment. The aim of the study was to identify new prognostic factors to select patients who need more intense treatment. Patients and Methods: Forty-three consecutive patients underwent surgery plus chemoradiotherapy for pathologically diagnosed high-grade gliomas (grade III, IV). Results: The median survival time was 989 days, and the 1-year survival rate was 87.6%. Among patients with grade IV disease, the median survival time, 1-year, and 2-year survival rate were 814 days, 82.6%, and 58.7%, respectively. In the univariate analysis, unmethylated MGMT promoter (p=0.0495), brainstem infiltration (p=0.0004), basal ganglia as the primary lesion site (p=0.0056), 3-dimensional conformal radiotherapy (p=0.0286), and <50 Gy (p=0.0049) were associated with a poor prognosis. In the multivariate analysis, only brainstem infiltration retained significance (HR for death, 0.21; 95% CI=0.06-0.70; p=0.011). Conclusion: Brainstem infiltration is a novel prognostic factor for poor prognosis in patients with high-grade gliomas. ER -