RT Journal Article
SR Electronic
T1 Pretreatment MRI in Primary Rectal Cancer as a Predictor for Oncological Outcomes After Surgery for Local Recurrence
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2459
OP 2465
DO 10.21873/anticanres.15021
VO 41
IS 5
A1 ANDERS H. ELLIOT
A1 BARWAR N. OTHMAN
A1 CHIKAKO SUZUKI
A1 LENNART BLOMQVIST
A1 ANNA MARTLING
A1 HEMMING JOHANSSON
A1 BENGT GLIMELIUS
A1 PER J. NILSSON
A1 HENRIK IVERSEN
YR 2021
UL http://ar.iiarjournals.org/content/41/5/2459.abstract
AB Background/Aim: For patients with locally recurrent rectal cancer (LRRC) extensive surgery is often the only curative option and patient selection is crucial. This study aimed to investigate whether magnetic resonance imaging (MRI) characteristics of the primary tumour can predict oncological outcome after surgery for locally recurrent rectal cancer (LRRC). Patients and Methods: All patients undergoing surgery for LRRC with a curative intent at the Karolinska University Hospital 2003-2013 were included. MRI examinations of the primary tumour were re-evaluated. Results: In total, 54 patients were included. A tumour volume decrease of <70% after preoperative radiotherapy or chemoradiotherapy (C)RT for the primary tumour was correlated with a lower proportion of R0 resection of the LRRC (OR=0.07, 95% CI=0.01-0.84). No association between MRI characteristics of the primary tumour and prognosis after LRRC surgery was found. Conclusion: Long-term outcomes after surgery for LRRC were not significantly associated with MRI characteristics of the index tumour. However, factors associated with increased risk of R1 resection of LRRC were identified.