TY - JOUR T1 - Contribution of Interleukin-10 Genotype to Triple Negative Breast Cancer Risk JF - Anticancer Research JO - Anticancer Res SP - 2451 LP - 2457 DO - 10.21873/anticanres.15020 VL - 41 IS - 5 AU - KAI-YUAN CHEN AU - WEI-CHING CHIEN AU - JIUAN-MIAW LIAO AU - CHIA-WEN TSAI AU - WEN-SHIN CHANG AU - CHEN-HSIEN SU AU - SHIH-WEI HSU AU - HWEI-CHUNG WANG AU - DA-TIAN BAU Y1 - 2021/05/01 UR - http://ar.iiarjournals.org/content/41/5/2451.abstract N2 - Background/Aim: Triple negative breast cancer (TNBC) is characterized by increased recurrence and poor survival. Mounting evidence suggests that interleukin-10 (IL-10) plays a role in carcinogenesis, however, little is known about the contribution of IL-10 to TNBC. The study evaluated the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genotypes to the risk of TNBC. Materials and Methods: IL-10 genotypes were examined among 1,232 breast cancer patients and 1,232 controls and evaluated. Results: The percentages of AG and GG for IL-10 A-1082G genotypes were higher in the breast cancer patient group than in the control group. The GG genotype carriers were of higher risk for breast cancer [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.28-3.21, p=0.0021]. Interestingly, G allele carriers were of higher risk of TNBC (OR=1.25, 95%CI=1.07-1.46, p=0.0050). Conclusion: The G allele of IL-10 A-1082G genotype may serve as a predictor for TNBC risk. The finding should be validated in other populations. ER -