RT Journal Article SR Electronic T1 Solitary Parenchymal Splenic Recurrence of Ovarian Adenocarcinoma: A Case Report and Review of the Literature JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1471 OP 1476 VO 25 IS 2B A1 TSERKEZOGLOU, ALIKI A1 KONTOU, SOFIA A1 HATJIELEFTHERIOU, GEORGE A1 NIKOLAIDOU, MARIA-EVANGELLIA A1 PLATANIOTIS, GEORGE A1 APOSTOLIKAS, NIKIFOROS A1 MAGIAKOS, GEORGE YR 2005 UL http://ar.iiarjournals.org/content/25/2B/1471.abstract AB We report a rare case of solitary parenchymal splenic recurrence of epithelial ovarian cancer which developed 27 months after the initial treatment. The patient, a 53-year-old woman, with a history of breast cancer, underwent total abdominal hysterectomy bilateral salpingo-ophorectomy (TAH & BSO), omentectomy and pelvic lymph node sampling for a serous carcinoma of the ovaries (stage IIIB). She subsequently received 6 cycles of cisplatinum chemotherapy. During follow-up, rising CA 125 serum levels heralded the 6 x 6 cm parenchymal splenic lesion which was documented by CT scan. She underwent splenectomy after pneumococcal vaccination, sandostatin and chemoprophylaxis. Histopathological evaluation revealed metastatic parenchymal disease consistent with recurrent ovarian cancer. She remains alive and disease-free for 20 months since the last operation. Isolated parenchymal splenic lesions are very rare and may occur as a late recurrence in epithelial ovarian cancer. Splenectomy can be performed with acceptable morbidity and confers a substantial survival benefit to patients. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved