RT Journal Article SR Electronic T1 Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2485 OP 2488 DO 10.21873/anticanres.15025 VO 41 IS 5 A1 AARON HAAG A1 DEANNA HUFFMAN A1 CHELSEA PETERSON A1 KARTHIK SHANKAR A1 LYNNA ALNIMER A1 YAZAN SAMHOURI A1 LARISA GREENBERG YR 2021 UL http://ar.iiarjournals.org/content/41/5/2485.abstract AB Background/Aim: Cutaneous manifestations of disease are exceedingly rare and commonly overlooked in clinical practice. Allergies or contact dermatitis, autoimmune disease or skin cancer are the most common conditions typically associated with skin lesions. Rarely, cutaneous lesions may be the first sign of internal malignancy, or even resemble recurrent disease in those with history of cancer. Case Report: Herein, we report a case of an otherwise healthy male who presented to his primary care provider (PCP) with a skin lesion misdiagnosed as a furuncle, which eventually led to diagnosis of metastatic esophageal cancer. The patient was a 64-year-old male, presenting with a fungating lesion on the tip of his nose which was biopsied, confirming adenocarcinoma likely from a gastrointestinal source. Staging imaging showed extensive lung, liver, and boney metastatic disease. He was initially treated with chemotherapy and trastuzumab. Conclusion: Cutaneous lesions are a rare presenting sign of malignancy, but rapidly growing lesions should be evaluated for possible metastatic disease.