RT Journal Article
SR Electronic
T1 Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2117
OP 2122
DO 10.21873/anticanres.14983
VO 41
IS 4
A1 WATANABE, TAKUO
A1 SHIOZAWA, MANABU
A1 KIMURA, YAYOI
A1 HIROSHIMA, YUKIHIKO
A1 HASHIMOTO, ITARU
A1 KOMORI, KEISUKE
A1 WATANABE, HAYATO
A1 KANO, KAZUKI
A1 FUJIKAWA, HIROHITO
A1 AOYAMA, TORU
A1 NUMATA, MASAKATSU
A1 YAMADA, TAKANOBU
A1 TAMAGAWA, HIROSHI
A1 OGATA, TAKASHI
A1 YUKAWA, NORIO
A1 MORINAGA, SOICHIRO
A1 RINO, YASUSHI
A1 MASUDA, MUNETAKA
A1 MIYAGI, YOHEI
A1 OSHIMA, TAKASHI
YR 2021
UL http://ar.iiarjournals.org/content/41/4/2117.abstract
AB Background/Aim: Stanniocalcin2 (STC2) is associated with proliferation, invasion, and metastasis in various cancers. We examined the clinical significance of STC2 mRNA expression in patients with colorectal cancer (CRC). Patients and Methods: Relative expression levels of STC2 mRNA in CRC tissues and corresponding normal mucosa obtained from 202 patients were measured using quantitative real-time reverse transcriptase-polymerase chain reaction. Results: Expression of STC2 mRNA was higher in the cancer tissue than in the adjacent normal mucosa. STC2 mRNA expression in cancer tissues was associated with tumour size, liver metastasis, venous invasion, and lymph node metastasis. High expression of STC2 mRNA was significantly associated with poorer postoperative survival (p=0.0003). Multivariate analysis showed that high expression of STC2 mRNA was an independent predictor of postoperative survival. Conclusion: High expression of STC2 mRNA in CRC tissue may be a useful prognostic marker in patients with CRC.