TY - JOUR T1 - Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 2117 LP - 2122 DO - 10.21873/anticanres.14983 VL - 41 IS - 4 AU - TAKUO WATANABE AU - MANABU SHIOZAWA AU - YAYOI KIMURA AU - YUKIHIKO HIROSHIMA AU - ITARU HASHIMOTO AU - KEISUKE KOMORI AU - HAYATO WATANABE AU - KAZUKI KANO AU - HIROHITO FUJIKAWA AU - TORU AOYAMA AU - MASAKATSU NUMATA AU - TAKANOBU YAMADA AU - HIROSHI TAMAGAWA AU - TAKASHI OGATA AU - NORIO YUKAWA AU - SOICHIRO MORINAGA AU - YASUSHI RINO AU - MUNETAKA MASUDA AU - YOHEI MIYAGI AU - TAKASHI OSHIMA Y1 - 2021/04/01 UR - http://ar.iiarjournals.org/content/41/4/2117.abstract N2 - Background/Aim: Stanniocalcin2 (STC2) is associated with proliferation, invasion, and metastasis in various cancers. We examined the clinical significance of STC2 mRNA expression in patients with colorectal cancer (CRC). Patients and Methods: Relative expression levels of STC2 mRNA in CRC tissues and corresponding normal mucosa obtained from 202 patients were measured using quantitative real-time reverse transcriptase-polymerase chain reaction. Results: Expression of STC2 mRNA was higher in the cancer tissue than in the adjacent normal mucosa. STC2 mRNA expression in cancer tissues was associated with tumour size, liver metastasis, venous invasion, and lymph node metastasis. High expression of STC2 mRNA was significantly associated with poorer postoperative survival (p=0.0003). Multivariate analysis showed that high expression of STC2 mRNA was an independent predictor of postoperative survival. Conclusion: High expression of STC2 mRNA in CRC tissue may be a useful prognostic marker in patients with CRC. ER -