RT Journal Article
SR Electronic
T1 Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2123
OP 2132
DO 10.21873/anticanres.14984
VO 41
IS 4
A1 GIANLUCA VANNI
A1 MARCO MATERAZZO
A1 MARCO PELLICCIARO
A1 SADRI AMIR
A1 FEDERICO TACCONI
A1 VINCENZO AMBROGI
A1 ORESTE CLAUDIO BUONOMO
YR 2021
UL http://ar.iiarjournals.org/content/41/4/2123.abstract
AB Background/Aim: Surgical stress has been correlated with higher rate of postoperative complications. Breast implants’ surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction. Patients and Methods: Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance. Results: Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group. Conclusion: Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.