TY - JOUR T1 - Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor JF - Anticancer Research JO - Anticancer Res SP - 2039 LP - 2044 DO - 10.21873/anticanres.14972 VL - 41 IS - 4 AU - STEFFEN KOERDT AU - JAN-DIRK RAGUSE AU - FELIX NEUMANN AU - BENEDICTA BECK-BROICHSITTER AU - KILIAN KREUTZER AU - KONRAD NEUMANN AU - MAX HEILAND AU - CHRISTIAN DOLL Y1 - 2021/04/01 UR - http://ar.iiarjournals.org/content/41/4/2039.abstract N2 - Background/Aim: The aim of the present study was to assess the value of panendoscopy of the upper aero-digestive tract in the identification of synchronous tumors in OSCC patients without clinical signs of a second primary tumor. Patients and Methods: In this retrospective study, patients diagnosed with a primary OSCC who received surgical therapy between January 1st, 2012 and December 31st, 2017 were included. Participants must have undergone panendoscopy during the staging process. None of these patients showed clinical signs of a second primary tumor. Results: A total of 265 patients (99 females and 166 males; mean age=63.3 years, range=26-96 years) were included. The mean (SD) follow-up was 25.88 (±20.479 SD) months. Five synchronous secondary tumors (1.9%) could be identified within this cohort. Of these, only two (0.8%) were located within the area of panendoscopy and were diagnosed in patients with regular alcohol and/or tobacco abuse. Eighteen metachronous second primary tumors were diagnosed, 10 being located within the upper aero-digestive tract. Conclusion: The relevance of routinely performed panendoscopy in patients suffering from an oral squamous cell carcinoma without clinical signs of a secondary tumor should be critically re-evaluated, especially in patients without typical risk factors. ER -