RT Journal Article
SR Electronic
T1 Prognostic Value and Therapeutic Implications of Pleural Carcinosis and Malignant Pleural Effusion in Advanced Epithelial Ovarian Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2033
OP 2038
DO 10.21873/anticanres.14971
VO 41
IS 4
A1 SARA NASSER
A1 CHRISTINA FOTOPOULOU
A1 ROLF RICHTER
A1 JANA KAULICH
A1 ELENA BRAICU
A1 CARMEN BETETA
A1 JESSICA OLSCHEWSKI
A1 AYGUN BABAYEVA
A1 JALID SEHOULI
YR 2021
UL http://ar.iiarjournals.org/content/41/4/2033.abstract
AB Aim: To demonstrate the prognostic value of pleural carcinosis/effusion in a cohort of patients with advanced epithelial ovarian cancer (EOC) and the associated therapeutic implications. Patients and Methods: Overall, data for 388 patients with EOC with confirmed malignant pleural effusion (MPE) or pleural carcinosis were retrospectively analyzed. Exclusion criteria were non-epithelial ovarian malignancies and presence of other comorbidities associated with pleural effusions. Results: The prognosis after the occurrence of MPE during the EOC in relapsed cases was poor with an overall survival of 9.9 months. In the multivariate analysis, the time point of the manifestation of the pleural effusion (p<0.001), platinum sensitivity (p=0.003), performance status (p=0.045) and presence of ascites (p=0.004) were significant prognostic factors for overall survival. Conclusion: Even in this less favorable collective, well-established EOC prognostic factors were associated with a significantly better overall survival. This suggests that the overall behavioral pattern of the disease has strong similarities in patients with and without pleural effusion or carcinosis and merits an equally high therapeutic effort.