RT Journal Article
SR Electronic
T1 Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1803
OP 1810
DO 10.21873/anticanres.14946
VO 41
IS 4
A1 HIROTO NISHINO
A1 MASAYUKI OKUNO
A1 SATORU SEO
A1 REI TODA
A1 KENJI YOSHINO
A1 YOSUKE KASAI
A1 MOTOHIKO SATOH
A1 KEIKO IWAISAKO
A1 KOJIRO TAURA
A1 ETSURO HATANO
YR 2021
UL http://ar.iiarjournals.org/content/41/4/1803.abstract
AB Background/Aim: Sinusoidal obstruction syndrome (SOS) after neoadjuvant chemotherapy with oxaliplatin for colorectal liver metastases (CRLM) has been reported to lead to early recurrence. This study investigated the effects of SOS on the development of CRLM in a rat model. Materials and Methods: RCN-H4 cells were injected into the spleen or liver of ten monocrotaline-treated (SOS group) and ten untreated (control group) rats. The number and size of liver tumors were compared between the groups. Results: The number of liver tumors in the splenic RCN-H4 injection model was significantly higher in the SOS group than in the control group (332±213 vs. 16±5, p=0.029); however, the largest tumor diameter in the hepatic model was similar between groups (6.2±1.8 vs. 6.4±2.4 mm, p=0.87). Conclusion: SOS promotes CRLM development by splenic RCN-H4 cell injection. This might be due to the higher incidence of cancer cell implantation into the liver.