TY - JOUR T1 - Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model JF - Anticancer Research JO - Anticancer Res SP - 1803 LP - 1810 DO - 10.21873/anticanres.14946 VL - 41 IS - 4 AU - HIROTO NISHINO AU - MASAYUKI OKUNO AU - SATORU SEO AU - REI TODA AU - KENJI YOSHINO AU - YOSUKE KASAI AU - MOTOHIKO SATOH AU - KEIKO IWAISAKO AU - KOJIRO TAURA AU - ETSURO HATANO Y1 - 2021/04/01 UR - http://ar.iiarjournals.org/content/41/4/1803.abstract N2 - Background/Aim: Sinusoidal obstruction syndrome (SOS) after neoadjuvant chemotherapy with oxaliplatin for colorectal liver metastases (CRLM) has been reported to lead to early recurrence. This study investigated the effects of SOS on the development of CRLM in a rat model. Materials and Methods: RCN-H4 cells were injected into the spleen or liver of ten monocrotaline-treated (SOS group) and ten untreated (control group) rats. The number and size of liver tumors were compared between the groups. Results: The number of liver tumors in the splenic RCN-H4 injection model was significantly higher in the SOS group than in the control group (332±213 vs. 16±5, p=0.029); however, the largest tumor diameter in the hepatic model was similar between groups (6.2±1.8 vs. 6.4±2.4 mm, p=0.87). Conclusion: SOS promotes CRLM development by splenic RCN-H4 cell injection. This might be due to the higher incidence of cancer cell implantation into the liver. ER -