TY - JOUR T1 - Have Volume-based Parameters of Positron Emission Tomography/Computed Tomography Prognostic Relevance for Patients With Potentially Platinum-responsive Recurrent Ovarian Cancer? A Single Center Italian Study JF - Anticancer Research JO - Anticancer Res SP - 1937 LP - 1944 DO - 10.21873/anticanres.14960 VL - 41 IS - 4 AU - ANGIOLO GADDUCCI AU - ENRICO SIMONETTI AU - FEDERICA GUIDOCCIO AU - GIANPIERO MANCA AU - ASSUERO GIORGETTI AU - TOMMASO DEPALO AU - STEFANIA COSIO AU - MARIO MICCOLI AU - DUCCIO VOLTERRANI Y1 - 2021/04/01 UR - http://ar.iiarjournals.org/content/41/4/1937.abstract N2 - Background/Aim: To assess the prognostic relevance of volume-based parameters [whole body (wb)-metabolic tumor volume (MTV) and wb-total lesion glycolysis (TLG)] of pretreatment PET/CT in patients with potentially platinum-responsive recurrent ovarian cancer. Patients and Methods: This retrospective investigation analyzed 67 patients at first relapse. Results: At univariate analysis, post-relapse survival and overall survival correlated with residual disease after primary surgery (RD) (p=0.015 and 0.049, respectively), time to recurrence (p=0.005 and p=0.0003), number of recurrence sites (p=0.001 and p=0.0005), treatment at recurrence (p=0.044 and 0.043) and wb-MTV (p=0.023 and 0.021) but not with wb-TLG. RD, time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic variables for post-relapse survival, and time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic factors for overall survival. Conclusion: Volume-based parameters of PET/CT are not independent predictors of clinical outcome in potentially platinum-responsive recurrent ovarian cancer. ER -