RT Journal Article
SR Electronic
T1 Tumor Size and N2 Lymph Node Metastasis Are Significant Risk Factors for Early Recurrence in Completely Resected Centrally Located Primary Lung Cancer Patients
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2165
OP 2169
DO 10.21873/anticanres.14989
VO 41
IS 4
A1 TAKUMA TSUKIOKA
A1 NOBUHIRO IZUMI
A1 HIROAKI KOMATSU
A1 HIDETOSHI INOUE
A1 HIKARU MIYAMOTO
A1 RYUICHI ITO
A1 TAKUYA KIMURA
A1 NORITOSHI NISHIYAMA
YR 2021
UL http://ar.iiarjournals.org/content/41/4/2165.abstract
AB Background/Aim: In centrally-located lung cancer treatment, it is difficult to attain a sufficient resection margin. It is important to investigate recurrent styles in centrally-located lung cancer patients. Patients and Methods: Primary lung cancer located at the hilar area that requires pneumonectomy or sleeve lobectomy is defined as centrally-located lung cancer. Early recurrence was defined as that within 1 year after surgery. Results: This study included 43 centrally-located lung cancer patients. Ten patients underwent pneumonectomy and 33 underwent sleeve lobectomy. Eleven patients experienced early recurrence. Non-squamous cell carcinoma (p=0.012), tumor size>64 mm (p<0.001) and pathological N2 (p=0.012) were significant predictors for early recurrence by univariate analysis. Also, tumor size >64 mm (p=0.006) and pathological N2 (p=0.019) were independent predictors by multivariate analysis. Conclusion: Non-squamous cell carcinoma, tumor size and pathological N2 were significant predictors of early recurrence in centrally-located lung cancer. The type of surgical procedure did not affect recurrence development.