RT Journal Article
SR Electronic
T1 How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2101
OP 2110
DO 10.21873/anticanres.14981
VO 41
IS 4
A1 FERINI, GIANLUCA
A1 TRIPOLI, ANTONELLA
A1 MOLINO, LAURA
A1 CACCIOLA, ALBERTO
A1 LILLO, SARA
A1 PARISI, SILVANA
A1 UMINA, VINCENZA
A1 ILLARI, SALVATORE IVAN
A1 MARCHESE, VALENTINA ANNA
A1 CRAVAGNO, IRENE RITA
A1 BORZÌ, GIUSEPPINA RITA
A1 VALENTI, VITO
YR 2021
UL http://ar.iiarjournals.org/content/41/4/2101.abstract
AB Background/Aim: To evaluate if topical support therapy during static-intensity modulated radiotherapy (sIMRT) course is able to equal the characteristic minimum risk for radiation proctitis of Image-guided volumetric modulated arc therapy (IG-VMAT) treatment among localized prostate cancer patients. Patients and Methods: Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids. Results: Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance. Conclusion: Topical medications might have a role in radiation proctitis prevention.